AI told you so: navigating protein structure prediction in the era of machine learning.
Sami Chaaban, Giedrė Ratkevičiūtė, Clinton Lau; Biochem (Lond) 2024; doi: https://doi.org/10.1042/bio_2024_118
Molecular mechanism of dynein-dynactin activation by JIP3 and LIS1.
Singh K*, Lau CK*, Manigrasso G, Gama JB, Gassmann R, Carter AP. bioRXiv. 2023 Aug 17; https://doi.org/10.1101/2022.08.17.504273.
The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein.
Garner KEL*, Salter A*, Lau CK, Gurusaran M, Villemant C, Granger EP, McNee G, Woodman PG, Davies OR, Burke BE^, Allan VJ^. J Cell Biol. 2023 May 1; https://doi.org/10.1083/jcb.202204042.
Reconstitution of Dynein/Dynactin Transport Using Recombinant Dynein.
Lau CK. Dynein, Methods in Molecular Biology; 2023 Jan 1; https://doi.org/10.1007/978-1-0716-2958-1_9.
Cryo-EM reveals the complex architecture of dynactin’s shoulder and pointed end.
Lau CK, O’Reilly FJ, Santhanam B, Lacey SE, Rappsilber J, Carter AP. EMBO J. 2021 Mar 18;e106164.
Shulin packages axonemal outer dynein arms for ciliary targeting.
Mali GR*, Abid Ali F*, Lau CK*, Begum F, Boulanger J, Howe JD, Chen ZA, Rappsilber J, Skehel M, Carter AP. Science. 2021 Feb 26;371(6532):910-916.
Structure-guided design of a synthetic mimic of an EPCR-binding PfEMP1 protein.
Barber NM*, Lau CK*, Turner L*, Watson G, Thrane S, Lusingu JP, Lavstsen T, Higgins MK. mSphere. 2021 Jan 6; 6:e01081-20.
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Urnavicius L*, Lau CK*, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP. Nature. 2018 Feb 7;554(7691):202-206.
Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.Cell Host Microbe.
Lennartz F*, Adams Y*, Bengtsson A*, Olsen RW, Turner L, Ndam NT, Ecklu-Mensah G, Moussiliou A, Ofori MF, Gamain B, Lusingu JP, Petersen JE, Wang CW, Nunes-Silva S, Jespersen JS, Lau CK, Theander TG, Lavstsen T, Hviid L, Higgins MK, Jensen AT. 2017 Mar 8;21(3):403-414.
Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.
Lau CK*, Turner L*, Jespersen JS, Lowe ED, Petersen B, Wang CW, Petersen JE, Lusingu J, Theander TG, Lavstsen T, Higgins MK. Cell Host Microbe. 2015 Jan 14;17(1):118-29.
